The Application of Evidence-Based Medicine in Individualized Medicine

The fundamental aim of healthcare is to improve overall health the population by providing state-of-the-art for individuals at an affordable cost. foundation this system largely referred as “evidence-based medicine”. Too often, evidence-based medicine based solely on so-called “best research evidence”, collected through randomized controlled trials while disregarding clinical expertise and patient expectations. As gravitates towards personalized individualized medicine, such external (research) evidence can inform, but never replace, individual expertise. This applies in particular orphan diseases, which are methodologically particularly problematic, derived from them often questionable. Evidence-based constitutes a complex process allow doctors patients select best possible solutions each rapidly developing new therapeutic directions. requires revisit foundations medicine. A proposition how manage data immune-oncology presented here.